Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.44 |
| ▸ | GRN | P28799 | 2/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086994 | 0.91 | CTSL (0.47) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL7384652 | 0.84 | CTSK (0.52) | CTSLCTSBCTSS | |
| SCHEMBL3824323 | 0.81 | CTSS (0.71) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL2400100 | 0.81 | CTSS (0.71) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL2400096 | 0.81 | CTSS (0.71) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL7303476 | 0.79 | TYR (0.46) | CTSLCTSBCTSS | |
| SCHEMBL7303468 | 0.79 | TYR (0.46) | CTSLCTSBCTSS | |
| SCHEMBL5134409 | 0.77 | CTSL (0.72) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL8169761 | 0.77 | ITGB3 (0.50) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL33526555 | 0.76 | ITGB3 (0.57) | CTSLCTSBCTSSITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |