Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | KYNU | Q16719 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983383 | 0.91 | CTSL (0.50) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL3044553 | 0.80 | CTSS (0.70) | CTSLCTSBCTSSKYNUALDH1A1 | |
| SCHEMBL33526968 | 0.77 | KLK5 (0.50) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL7384652 | 0.77 | CTSK (0.52) | CTSLCTSBCTSS | |
| SCHEMBL12241473 | 0.77 | KLK5 (0.50) | CTSLCTSBCTSSITGB3ITGA2B | |
| SCHEMBL7086316 | 0.75 | NPC1 (0.52) | CTSLCTSBCTSSKYNUALDH1A1 | |
| SCHEMBL8169761 | 0.74 | ITGB3 (0.50) | CTSLCTSBCTSSALDH1A1ALOX15 | |
| SCHEMBL7303468 | 0.74 | TYR (0.46) | CTSLCTSBCTSSPOLBTSHR | |
| SCHEMBL7303476 | 0.74 | TYR (0.46) | CTSLCTSBCTSSPOLBTSHR | |
| SCHEMBL25516818 | 0.74 | CTSL (0.53) | CTSLCTSBCTSSKYNUALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |