Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 10/20 | 0.40 |
| ▸ | RAB9A | P51151 | 9/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15347875 | 1.00 | POLB (0.41) | POLBNPC1RAB9AL3MBTL1CYP2C19 | |
| SCHEMBL7878676 | 0.78 | TAAR1 (0.38) | POLBNPC1RAB9AL3MBTL1CYP2C19 | |
| SCHEMBL6983491 | 0.77 | CYP2C19 (0.42) | POLBNPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL9558609 | 0.76 | HPGD (0.38) | POLBNPC1RAB9AADRA2AADRA2B | |
| SCHEMBL9558559 | 0.76 | HPGD (0.38) | POLBNPC1RAB9AADRA2AADRA2B | |
| SCHEMBL9558342 | 0.74 | SMN1; SMN2 (0.40) | RAB9AL3MBTL1CYP2C19ADRA2AADRA2B | |
| SCHEMBL19433080 | 0.73 | ALDH1A1 (0.47) | POLBALDH1A1GAA | |
| SCHEMBL18840201 | 0.73 | ALDH1A1 (0.47) | POLBALDH1A1GAA | |
| SCHEMBL13299214 | 0.73 | NPC1 (0.50) | POLBNPC1RAB9AL3MBTL1CYP2C19 | |
| SCHEMBL9744645 | 0.73 | ALDH1A1 (0.38) | POLBNPC1RAB9AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991643-B1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-0991643-A1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| US-5945430-A | BENZO(5,6)CYCLOHEPTAPYRIDINE COMPOUNDS THAT INHIBIT RAS FUNCTION, USE FOR TREATING TUMOR CELLS EXPRESSING AN ACTIVATED RAS ONCOGENE IN MAMMALS | SCHERING CORPORATION (US) | 1999-08-31 | — | — | US | disclosed |
| WO-1998057965-A1 | NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |