Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 7/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28496001 | 0.83 | MAPT (0.36) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL11273327 | 0.82 | MEN1 (0.44) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8175589 | 0.79 | KDM4E (0.48) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL455218 | 0.79 | DCLRE1A (0.42) | MAPTKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL5915596 | 0.79 | TAAR1 (0.49) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29068251 | 0.78 | SMN1; SMN2 (0.42) | MAPTKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6273154 | 0.77 | MAPT (0.46) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL547665 | 0.76 | LMNA (0.50) | ALDH1A1MEN1KMT2AERN1SMN1; SMN2 | |
| SCHEMBL6141027 | 0.76 | ADRB2 (0.42) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL456713 | 0.75 | ESR2 (0.50) | MAPTKDM4EALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244446-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1244446-A1 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001039773-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-07 | — | — | WO | disclosed |