Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989503 | 0.93 | MAPKAPK2 (0.49) | MAPKAPK2MEN1KMT2ACSF1RGPR139 | |
| SCHEMBL6985543 | 0.91 | MAPKAPK2 (0.50) | MAPKAPK2MEN1KMT2ABRAFCSF1R | |
| SCHEMBL6988227 | 0.86 | MAPKAPK2 (0.49) | MAPKAPK2ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6986333 | 0.82 | MEN1 (0.48) | MEN1KMT2APOLBBRAFCSF1R | |
| SCHEMBL6983717 | 0.80 | MAPKAPK2 (0.46) | MAPKAPK2MEN1KMT2ABRAFCSF1R | |
| SCHEMBL6984652 | 0.79 | ABCC9 (0.51) | MAPKAPK2MEN1KMT2ABRAFCSF1R | |
| SCHEMBL6988592 | 0.79 | KCNJ11 (0.54) | MAPKAPK2MEN1KMT2ABRAFCSF1R | |
| SCHEMBL6984659 | 0.78 | ABCC9 (0.47) | MAPKAPK2MEN1KMT2ABRAFCSF1R | |
| SCHEMBL6989571 | 0.78 | KMT2A (0.50) | MAPKAPK2MEN1KMT2APOLBGPR139 | |
| SCHEMBL6989589 | 0.78 | CCR6 (0.44) | MAPKAPK2KMT2ANPC1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |