Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 10/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989571 | 0.92 | KMT2A (0.50) | CCR6CXCR2NPC1RAB9AALDH1A1 | |
| SCHEMBL6985970 | 0.79 | NPC1 (0.42) | CCR6CXCR2NPC1RAB9AALDH1A1 | |
| SCHEMBL6983720 | 0.78 | MAPKAPK2 (0.49) | NPC1RAB9ASMN1; SMN2MAPKAPK2KMT2A | |
| SCHEMBL6989503 | 0.78 | MAPKAPK2 (0.49) | CCR6ALDH1A1MAPKAPK2CYP3A4CYP2C9 | |
| SCHEMBL6989585 | 0.77 | LMNA (0.41) | CXCR2NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6985543 | 0.75 | MAPKAPK2 (0.50) | MAPKAPK2CYP3A4CYP2C9KMT2A | |
| SCHEMBL6988227 | 0.74 | MAPKAPK2 (0.49) | MAPKAPK2CYP3A4CYP2C9 | |
| SCHEMBL6983249 | 0.74 | KMT2A (0.44) | NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL6988220 | 0.73 | NPC1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6981005 | 0.73 | POLB (0.42) | NPC1RAB9AALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |