Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989589 | 0.92 | CCR6 (0.44) | KMT2ACCR6ALDH1A1NPC1RAB9A | |
| SCHEMBL6985543 | 0.84 | MAPKAPK2 (0.50) | KMT2AMEN1MAPK1GPR139MAPKAPK2 | |
| SCHEMBL6985151 | 0.83 | KMT2A (0.55) | KMT2AMEN1POLBALDH1A1MAPK1 | |
| SCHEMBL6989095 | 0.80 | KMT2A (0.50) | KMT2AMEN1POLBALDH1A1MAPK1 | |
| SCHEMBL6985145 | 0.80 | KMT2A (0.56) | KMT2AMEN1CCR6POLBALDH1A1 | |
| SCHEMBL6983720 | 0.78 | MAPKAPK2 (0.49) | KMT2AMEN1POLBHTTGPR139 | |
| SCHEMBL6989503 | 0.75 | MAPKAPK2 (0.49) | KMT2AMEN1CCR6ALDH1A1MAPK1 | |
| SCHEMBL6983249 | 0.74 | KMT2A (0.44) | KMT2AMEN1POLBALDH1A1MAPK1 | |
| SCHEMBL6991687 | 0.73 | KMT2A (0.42) | KMT2AMEN1POLBALDH1A1MAPK1 | |
| SCHEMBL6985970 | 0.72 | NPC1 (0.42) | KMT2AMEN1CCR6POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |