Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.39 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | NEK4 | P51957 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983720 | 0.93 | MAPKAPK2 (0.49) | MAPKAPK2CSF1RGPR139TBXA2RTBXAS1 | |
| SCHEMBL6988227 | 0.90 | MAPKAPK2 (0.49) | MAPKAPK2AURKBCYP2C9ROCK1CYP3A4 | |
| SCHEMBL6985543 | 0.87 | MAPKAPK2 (0.50) | MAPKAPK2AURKBCYP2C9ROCK1CYP3A4 | |
| SCHEMBL6990458 | 0.81 | CSF1R (0.44) | MAPKAPK2CSF1RTBXA2RTBXAS1MEN1 | |
| SCHEMBL6989499 | 0.79 | MAPKAPK2 (0.45) | MAPKAPK2CYP2C9CYP3A4CSF1RTBXA2R | |
| SCHEMBL6990454 | 0.78 | ABCC9 (0.52) | MAPKAPK2CYP2C9ROCK1CYP3A4CSNK1G1 | |
| SCHEMBL6989589 | 0.78 | CCR6 (0.44) | MAPKAPK2CYP2C9CYP3A4CCR6ALDH1A1 | |
| SCHEMBL6989571 | 0.75 | KMT2A (0.50) | MAPKAPK2MAPK1GPR139CCR6MEN1 | |
| SCHEMBL6986333 | 0.74 | MEN1 (0.48) | CSF1RTBXA2RTBXAS1MEN1ALDH1A1 | |
| SCHEMBL6983717 | 0.73 | MAPKAPK2 (0.46) | MAPKAPK2CYP2C9CYP3A4CSF1RCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |