Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 10/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983720 | 0.91 | MAPKAPK2 (0.49) | MAPKAPK2BRAFCSF1RTBXA2RTBXAS1 | |
| SCHEMBL6989503 | 0.87 | MAPKAPK2 (0.49) | MAPKAPK2CYP3A4CYP2C9CYP2C19CSF1R | |
| SCHEMBL6988227 | 0.87 | MAPKAPK2 (0.49) | MAPKAPK2CYP3A4CYP2C9CYP2C19TBXA2R | |
| SCHEMBL6989571 | 0.84 | KMT2A (0.50) | MAPKAPK2GPR139MEN1KMT2AMAPK1 | |
| SCHEMBL6985065 | 0.80 | CYP3A4 (0.49) | MAPKAPK2BRAFCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6982343 | 0.78 | CYP1A2 (0.56) | MAPKAPK2BRAFCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7161076 | 0.76 | CYP1A2 (0.49) | MAPKAPK2BRAFCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6989589 | 0.75 | CCR6 (0.44) | MAPKAPK2CYP3A4CYP2C9KMT2A | |
| SCHEMBL6988714 | 0.71 | SIRT2 (0.43) | MAPKAPK2TBXA2RTBXAS1MEN1KMT2A | |
| SCHEMBL6987131 | 0.71 | GRM5 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |