Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220497 | 0.76 | ADAM17 (0.48) | GRIK1GRIK2CTSCMAPTADAM17 | |
| SCHEMBL6986484 | 0.76 | ADAM17 (0.48) | GRIK1GRIK2CTSCMAPTADAM17 | |
| SCHEMBL6220502 | 0.76 | ADAM17 (0.48) | GRIK1GRIK2CTSCMAPTADAM17 | |
| SCHEMBL6220496 | 0.76 | ADAM17 (0.48) | GRIK1GRIK2CTSCMAPTADAM17 | |
| SCHEMBL6220493 | 0.76 | ADAM17 (0.48) | GRIK1GRIK2CTSCMAPTADAM17 | |
| SCHEMBL6984686 | 0.76 | ADAM17 (0.48) | GRIK1GRIK2CTSCMAPTADAM17 | |
| SCHEMBL6987723 | 0.76 | CTSC (0.36) | GRIK1GRIK2CTSCMAPTMMP2 | |
| SCHEMBL7815835 | 0.76 | CTSC (0.36) | GRIK1GRIK2CTSCMAPTMMP2 | |
| SCHEMBL6942707 | 0.74 | CTSC (0.35) | GRIK1GRIK2CTSCMAPTLMNA | |
| SCHEMBL6945570 | 0.71 | LMNA (0.43) | GRIK1GRIK2MMP2MMP3AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |