Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ANXA2 | P07355 | 2/20 | 0.31 |
| ▸ | S100A10 | P60903 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944740 | 0.90 | CHRNB2 (0.36) | LMNAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL7812198 | 0.83 | CTSC (0.33) | CTSCMAOAMAOBGRIK1GRIK2 | |
| SCHEMBL6984922 | 0.83 | CTSC (0.33) | CTSCMAOAMAOBGRIK1GRIK2 | |
| SCHEMBL6946939 | 0.83 | MAOA (0.39) | LMNAL3MBTL1MAOAMAOBCACNA1B | |
| SCHEMBL7139769 | 0.82 | ANXA2 (0.38) | LMNAL3MBTL1MAOAMAOBCACNA1B | |
| SCHEMBL6940308 | 0.82 | MMP1 (0.41) | KMT2ASMN1; SMN2 | |
| SCHEMBL7940341 | 0.75 | F10 (0.32) | LMNAKMT2AMAPTHTT | |
| SCHEMBL6983883 | 0.74 | GRIK1 (0.37) | CTSCLMNAGRIK1GRIK2MAPT | |
| SCHEMBL7127180 | 0.72 | LMNA (0.33) | LMNAL3MBTL1MAOAMAOBCACNA1B | |
| SCHEMBL6987723 | 0.71 | CTSC (0.36) | CTSCLMNAGRIK1GRIK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |