Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.54 |
| ▸ | GSK3B | P49841 | 11/20 | 0.48 |
| ▸ | QPCT | Q16769 | 10/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677702 | 0.93 | IDH1 (0.61) | IDH1GSK3BQPCTJAK2PRKCB | |
| Trifluoroacetic Acid SCHEMBL6977475 | 0.86 | CAMK2D (0.48) | — | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.85 | CAMK2D (0.46) | GSK3BPRKCBPRKCAPRKCE | |
| Trifluoroacetic Acid SCHEMBL6984346 | 0.85 | PRKCA (0.50) | GSK3BPRKCBPRKCAPRKCE | |
| Trifluoroacetic Acid SCHEMBL6979888 | 0.85 | PRKACA (0.41) | GSK3BPRKCBPRKCAPRKCE | |
| Trifluoroacetic Acid SCHEMBL6978145 | 0.83 | CCNT1 (0.39) | PRKCA | |
| Trifluoroacetic Acid SCHEMBL6977279 | 0.83 | CAMK2D (0.41) | GSK3BPRKCBPRKCAPRKCE | |
| Trifluoroacetic Acid SCHEMBL6978585 | 0.83 | CCNT1 (0.40) | GSK3BPRKCBPRKCAPRKCE | |
| Trifluoroacetic Acid SCHEMBL6981733 | 0.81 | CAMK2D (0.42) | GSK3BPRKCBPRKCAPRKCE | |
| Trifluoroacetic Acid SCHEMBL6986763 | 0.80 | TPSAB1 (0.38) | PRKCBPRKCAPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |