Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 9/20 | 0.50 |
| ▸ | PRKACA | P17612 | 3/20 | 0.50 |
| ▸ | PRKACG | P22612 | 3/20 | 0.50 |
| ▸ | PRKACB | P22694 | 3/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | PRKCB | P05771 | 8/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 7/20 | 0.43 |
| ▸ | PRKCH | P24723 | 3/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975188 | 0.93 | PRKCA (0.57) | PRKCAPRKACAPRKACGPRKACBPIM1 | |
| Trifluoroacetic Acid SCHEMBL6977475 | 0.90 | CAMK2D (0.48) | PIM1CDK2CCNT1CDK9CCNA2 | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.89 | CAMK2D (0.46) | PRKCAPIM1PRKCBPRKCEPRKCH | |
| Trifluoroacetic Acid SCHEMBL6979888 | 0.89 | PRKACA (0.41) | PRKCAPRKACAPRKACGPRKACBPIM1 | |
| Trifluoroacetic Acid SCHEMBL6978145 | 0.87 | CCNT1 (0.39) | PRKCAPRKACAPRKACGPRKACBPIM1 | |
| Trifluoroacetic Acid SCHEMBL6978585 | 0.87 | CCNT1 (0.40) | PRKCAPRKACAPRKACGPRKACBPIM1 | |
| Trifluoroacetic Acid SCHEMBL6977279 | 0.87 | CAMK2D (0.41) | PRKCAPIM1PRKCBPRKCEPRKCH | |
| Trifluoroacetic Acid SCHEMBL6981733 | 0.85 | CAMK2D (0.42) | PRKCAPIM1PRKCBPRKCEPRKCH | |
| Trifluoroacetic Acid SCHEMBL6983900 | 0.85 | IDH1 (0.54) | PRKCAPRKCBPRKCEGSK3B | |
| Trifluoroacetic Acid SCHEMBL6986763 | 0.84 | TPSAB1 (0.38) | PRKCAPIM1PRKCBPRKCEPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |