Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ATR | Q13535 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | CETP | P11597 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27007682 | 0.94 | ADRB1 (0.52) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL19131011 | 0.84 | KDM4E (0.68) | SMN1; SMN2NPC1RAB9AMAPTATR | |
| SCHEMBL13218526 | 0.84 | RAB9A (0.61) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| Trifluoroacetic Acid SCHEMBL30745999 | 0.83 | P2RY14 (0.46) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL1359864 | 0.83 | ADRB1 (0.76) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL13218517 | 0.83 | DGAT1 (0.57) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL4422799 | 0.82 | ADRB1 (0.51) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL27007913 | 0.81 | CHRNB2 (0.49) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL27007665 | 0.79 | MAPKAPK2 (0.48) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL27007733 | 0.79 | ADRB1 (0.52) | ADRB1SMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007524-B1 | INDOLE DERIVATIVES AS 5-HT1B AND 5-HT1D AGONISTS | PF MEDICAMENT (FR) | 2003-11-12 | — | — | EP | disclosed |
| US-6589953-B2 | Treatment of anxiety, depression, aggressiveness, panic attacks, obsessive-compulsive disorders, schizophrenia, suicidal tendency, neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease | PIERRE FABRE MEDICAMENT (FR) | 2003-07-08 | — | — | US | disclosed |
| US-20020061891-A1 | Indole derivatives as 5-HT1B and 5-HT1D agonists | PEREZ MICHEL (FR) | 2002-05-23 | — | — | US | disclosed |
| US-6277853-B1 | FOR TREATMENT OF NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, MIGRAINES, ALCOHOLISM | PIERRE FABRE MEDICAMENT (FR) | 2001-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061891-A1 | Indole derivatives as 5-HT1B and 5-HT1D agonists | HTR1B, HTR1A, HTR1D | HTR3E 19/4885HTR3B 11/4885ADRB1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.