Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136906 | 0.79 | ACHE (0.63) | ACHEPOLBPTPN11MAPT | |
| SCHEMBL6986404 | 0.79 | POLB (0.48) | MEN1KMT2AHRH2HRH1LMNA | |
| SCHEMBL31705889 | 0.78 | ACHE (0.57) | MEN1KMT2AACHEPTPN11ALDH1A1 | |
| SCHEMBL31635767 | 0.76 | TRPV1 (0.51) | HRH2HRH1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL7243129 | 0.75 | KMT2A (0.53) | MEN1KMT2AHRH2HRH1LMNA | |
| SCHEMBL15188017 | 0.75 | ACHE (0.49) | ACHEHTT | |
| SCHEMBL27470853 | 0.74 | HRH4 (0.53) | MEN1KMT2APOLBOPRD1OPRK1 | |
| SCHEMBL1459682 | 0.74 | MAPT (0.57) | MEN1KMT2AHRH2HRH1LMNA | |
| SCHEMBL28070878 | 0.73 | MAPK8 (0.52) | ACHEPOLBSMN1; SMN2PTPN11ALDH1A1 | |
| SCHEMBL9405372 | 0.72 | POLB (0.73) | HRH2HRH1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093367-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1093367-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066925-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-29 | — | — | WO | disclosed |