Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812198 | 1.00 | CTSC (0.33) | CTSCPLA2G2AMAOAMAOBGRIK1 | |
| SCHEMBL6942707 | 0.83 | CTSC (0.35) | CTSCMAOAMAOBGRIK1GRIK2 | |
| SCHEMBL6944740 | 0.74 | CHRNB2 (0.36) | — | |
| SCHEMBL6946939 | 0.74 | MAOA (0.39) | MAOAMAOBGRIK1GRIK2 | |
| SCHEMBL7139769 | 0.72 | ANXA2 (0.38) | MAOAMAOBGRIK1GRIK2 | |
| SCHEMBL7815835 | 0.69 | CTSC (0.36) | CTSCGRIK1GRIK2 | |
| SCHEMBL6987723 | 0.69 | CTSC (0.36) | CTSCGRIK1GRIK2 | |
| SCHEMBL6983883 | 0.69 | GRIK1 (0.37) | CTSCGRIK1GRIK2 | |
| SCHEMBL6220493 | 0.67 | ADAM17 (0.48) | CTSCGRIK1GRIK2 | |
| SCHEMBL6220496 | 0.67 | ADAM17 (0.48) | CTSCGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |