Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986273 | 0.86 | HTR2B (0.34) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL6314507 | 0.83 | KDM4E (0.41) | KDM4EPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL6314505 | 0.83 | KDM4E (0.41) | KDM4EPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL6987657 | 0.81 | HTR2B (0.42) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10963143 | 0.79 | KDM4E (0.35) | KDM4EPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL6985038 | 0.76 | HTR2B (0.36) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6982545 | 0.75 | ALOX5 (0.33) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4952161 | 0.75 | TYR (0.35) | KDM4EPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL6985974 | 0.73 | KDM4E (0.37) | KDM4EPKMALDH1A1MAPTHPGD | |
| SCHEMBL11963453 | 0.70 | KDM4E (0.34) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1302467-A2 | Process for the preparation of substituted thiazoline derivatives and their intermediate | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2003-04-16 | — | — | EP | disclosed |