Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314507 | 1.00 | KDM4E (0.41) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL11963453 | 0.86 | KDM4E (0.34) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13390599 | 0.85 | TP53 (0.36) | ALDH1A1MEN1KMT2ASMN1; SMN2HIF1A | |
| SCHEMBL6321996 | 0.84 | HTR2B (0.35) | KDM4EALDH1A1SMN1; SMN2HIF1AMAPT | |
| SCHEMBL3300121 | 0.84 | HTR2B (0.35) | KDM4EALDH1A1SMN1; SMN2HIF1AMAPT | |
| SCHEMBL3332924 | 0.84 | MAPT (0.43) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL3332934 | 0.84 | MAPT (0.43) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL15047737 | 0.84 | LMNA (0.30) | LMNA | |
| SCHEMBL1317324 | 0.84 | KMT2A (0.37) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11963399 | 0.84 | KMT2A (0.37) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730917-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-9174948-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20130210870-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-8324397-B2 | Desferrithiocin polyether analogues | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| WO-2008115433-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | UNIVERSITY OF FLORIDA (US) | 2008-09-25 | — | — | WO | disclosed |
| US-6894170-B2 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2005-05-17 | — | — | US | disclosed |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | KRICH SYLVIA (AT) | 2005-05-12 | — | — | US | disclosed |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022645-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | HAMP, SLC40A1, FTH1 | KDM4E 1878/4885PKM 2522/4885ALDH1A1 4405/4885 |
| US-20030088105-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, RCOR1, MT-CO1 | KDM4E 4453/4885PKM 4388/4885ALDH1A1 106/4885 |
| US-20100093812-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | SLC40A1, HAMP, FTH1 | KDM4E 1655/4885PKM 2297/4885ALDH1A1 4214/4885 |
| US-20050101782-A1 | Process for the preparation of substituted thiazolines and their intermediates | CBR1, CBR3, MT-CO1 | KDM4E 4582/4885PKM 4332/4885ALDH1A1 95/4885 |
| US-20130210870-A1 | DESFERRITHIOCIN POLYETHER ANALOGUES | HAMP, SLC40A1, FTH1 | KDM4E 1878/4885PKM 2522/4885ALDH1A1 4405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.