Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842277 | 0.87 | SLC29A1 (0.42) | ALDH1A1HTTTAAR1SIGMAR1SLC29A1 | |
| SCHEMBL6986054 | 0.86 | SIGMAR1 (0.46) | SIGMAR1SHMT2SLC29A1POLBLMNA | |
| Hydrochloric Acid SCHEMBL5842883 | 0.85 | SIGMAR1 (0.46) | ALDH1A1HTTTAAR1SIGMAR1SHMT2 | |
| SCHEMBL5842908 | 0.82 | FGFR3 (0.42) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5841494 | 0.81 | FGFR3 (0.43) | ALDH1A1HTTTAAR1SIGMAR1 | |
| SCHEMBL6986270 | 0.78 | SLC29A1 (0.41) | SIGMAR1SHMT2SLC29A1LMNA | |
| SCHEMBL6986043 | 0.78 | SHMT2 (0.50) | ALDH1A1SHMT2SLC29A1POLBLMNA | |
| SCHEMBL6985289 | 0.78 | SIGMAR1 (0.40) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5842572 | 0.78 | MEN1 (0.40) | ALDH1A1HTTTAAR1SIGMAR1SHMT2 | |
| Hydrochloric Acid SCHEMBL5842442 | 0.77 | HTR7 (0.41) | ALDH1A1HTTTAAR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |