Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949929 | 0.82 | CYP2A6 (0.41) | HRH3AKR1C3CHRNA7HRH4FAAH | |
| SCHEMBL28152135 | 0.77 | PARP1 (0.50) | HRH3AKR1C3CHRNA7HTR2AHTR2C | |
| SCHEMBL13634946 | 0.77 | CHRNB2 (0.50) | HRH3CHRNA7HTR2AHTR2CKCNH2 | |
| Hydrochloric Acid SCHEMBL28334700 | 0.76 | PARP1 (0.49) | HRH3AKR1C3CHRNA7HTR2AHTR2C | |
| SCHEMBL9463940 | 0.76 | HRH3 (0.43) | HRH3AKR1C3CHRNA7 | |
| SCHEMBL16343091 | 0.75 | DRD2 (0.54) | HRH3AKR1C3 | |
| SCHEMBL13162089 | 0.74 | HRH3 (0.42) | HRH3AKR1C3CHRNA7HRH4 | |
| SCHEMBL16343134 | 0.74 | DRD2 (0.45) | HRH3AKR1C3 | |
| SCHEMBL16343124 | 0.74 | DRD2 (0.45) | HRH3AKR1C3 | |
| SCHEMBL16343236 | 0.74 | DRD2 (0.45) | HRH3AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |