Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978962 | 0.88 | POLB (0.51) | ATMPOLBHDAC1HDAC2RAB9A | |
| SCHEMBL6980676 | 0.84 | ALDH1A1 (0.39) | ATMPOLBITGB3ITGA2BITGB1 | |
| SCHEMBL6980709 | 0.80 | ITGB3 (0.71) | ATMPOLBITGB3ITGA2B | |
| SCHEMBL8906494 | 0.77 | CA1 (0.46) | POLBITGB3ITGA2BCA1CA2 | |
| SCHEMBL8906500 | 0.77 | CA1 (0.46) | POLBITGB3ITGA2BCA1CA2 | |
| SCHEMBL6978278 | 0.77 | KMT2A (0.47) | ATMPOLBITGB3ITGA2BHPGD | |
| SCHEMBL7321784 | 0.76 | ITGB3 (0.48) | ITGB3ITGA2BMMEACECA1 | |
| SCHEMBL7862257 | 0.76 | KMT2A (0.41) | ATMPOLBITGB3ITGA2BRAB9A | |
| SCHEMBL7389084 | 0.76 | HDAC1 (0.47) | POLBHDAC1HDAC2RAB9ANPC1 | |
| SCHEMBL8895885 | 0.75 | TSHR (0.46) | POLBHDAC1HDAC2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630366-B1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2003-01-02 | — | — | EP | claimed |