Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986812 | 0.89 | ALDH1A1 (0.40) | BCL2MDM2MCL1TSHRALDH1A1 | |
| SCHEMBL6982469 | 0.87 | CYP2C9 (0.39) | BCL2MDM2MCL1TSHRALDH1A1 | |
| SCHEMBL6987183 | 0.86 | TSHR (0.45) | BCL2MDM2MCL1TSHRALDH1A1 | |
| SCHEMBL6987419 | 0.84 | ALDH1A1 (0.43) | TSHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6983706 | 0.83 | HTT (0.36) | TSHRALDH1A1NPSR1HTTKMT2A | |
| SCHEMBL6987971 | 0.82 | HTT (0.38) | TSHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6986605 | 0.82 | HTT (0.48) | BCL2MDM2MCL1TSHRALDH1A1 | |
| SCHEMBL6983312 | 0.82 | HTT (0.37) | TSHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6986371 | 0.81 | ALDH1A1 (0.41) | BCL2MDM2MCL1TSHRALDH1A1 | |
| SCHEMBL6987355 | 0.81 | ALDH1A1 (0.38) | BCL2MDM2MCL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |