SCHEMBL6987355

SCHEMBL6987355

CC(C)n1nc(-c2cc(N)nn2-c2ccccc2)ccc1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.38
GAA P10253 1/20 0.38
RAB9A P51151 7/20 0.37
NPC1 O15118 6/20 0.37
SMN1; SMN2 Q16637 5/20 0.37
MAPT P10636 2/20 0.37
STAT1 P42224 1/20 0.37
BCL2 P10415 1/20 0.36
MDM2 Q00987 1/20 0.36
MCL1 Q07820 1/20 0.36
CYP1A2 P05177 1/20 0.36
MAPK1 P28482 1/20 0.36
CYP2C19 P33261 1/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
TSHR P16473 2/20 0.36
GFER P55789 1/20 0.36
NFKB1 P19838 2/20 0.36
NFKB2 Q00653 2/20 0.36
RELA Q04206 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6986371 0.85 ALDH1A1 (0.41) ALDH1A1GAARAB9ANPC1BCL2
SCHEMBL6986812 0.82 ALDH1A1 (0.40) ALDH1A1GAARAB9ANPC1SMN1; SMN2
SCHEMBL6985846 0.81 BCL2 (0.41) ALDH1A1GAASMN1; SMN2MAPTBCL2
SCHEMBL6982469 0.81 CYP2C9 (0.39) ALDH1A1GAASMN1; SMN2MAPTBCL2
SCHEMBL6981026 0.80 AGTR2 (0.40) ALDH1A1SMN1; SMN2MAPTMAPK1CYP2C19
SCHEMBL6987183 0.80 TSHR (0.45) ALDH1A1SMN1; SMN2BCL2MDM2MCL1
SCHEMBL6984657 0.80 GRM5 (0.35) ALDH1A1GAARAB9ANPC1MDM2
SCHEMBL6984055 0.79 TSHR (0.34) ALDH1A1GAASMN1; SMN2BCL2MDM2
SCHEMBL6981881 0.79 PDE10A (0.43) ALDH1A1GAAMDM2TSHRTP53
SCHEMBL6985626 0.79 SLC5A1 (0.43) RAB9ANPC1SMN1; SMN2MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313733-A1 PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-05-28 EP disclosed
WO-2002018382-A1 PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-03-07 WO disclosed