Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985846 | 0.89 | BCL2 (0.41) | ALDH1A1KMT2ATSHRSMN1; SMN2HTT | |
| SCHEMBL6982469 | 0.88 | CYP2C9 (0.39) | ALDH1A1KMT2ATSHRSMN1; SMN2HTT | |
| SCHEMBL6990503 | 0.88 | TSHR (0.39) | ALDH1A1KMT2ATSHRSMN1; SMN2HTT | |
| SCHEMBL6987183 | 0.87 | TSHR (0.45) | ALDH1A1TSHRSMN1; SMN2HTTNPSR1 | |
| SCHEMBL6987419 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL6979346 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KMT2ATSHRSMN1; SMN2HTT | |
| SCHEMBL6983706 | 0.84 | HTT (0.36) | ALDH1A1KMT2ATSHRSMN1; SMN2HTT | |
| SCHEMBL6987271 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KMT2ASMN1; SMN2HTTLMNA | |
| SCHEMBL6989453 | 0.84 | KMT2A (0.42) | ALDH1A1KMT2ATSHRSMN1; SMN2HTT | |
| SCHEMBL6986605 | 0.83 | HTT (0.48) | ALDH1A1KMT2ATSHRSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |