Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987417 | 0.87 | MAPT (0.54) | NISCHMAPK10PKMRAD52MAPT | |
| SCHEMBL6983307 | 0.80 | NOS3 (0.45) | NISCHMAPK10PKMRAD52MAOA | |
| SCHEMBL29820187 | 0.76 | MAPT (0.63) | NISCHMAPTDHFRMEN1KMT2A | |
| SCHEMBL1446528 | 0.76 | MAPT (0.63) | NISCHMAPTDHFRMEN1KMT2A | |
| SCHEMBL13651011 | 0.76 | DHFR (0.36) | NISCHMAPTDHFRDRD2DRD1 | |
| SCHEMBL810733 | 0.76 | MAPT (0.50) | NISCHMAPTDHFRMEN1KMT2A | |
| SCHEMBL29967345 | 0.76 | MAPT (0.50) | NISCHMAPTDHFRMEN1KMT2A | |
| SCHEMBL6985896 | 0.75 | MAOA (0.44) | MAPK10MAPTMAOANOS3NOS2 | |
| SCHEMBL84899 | 0.75 | MAOA (0.44) | NISCHMAPK10MAOANOS3NOS2 | |
| SCHEMBL4113361 | 0.74 | MAOA (0.41) | NISCHMAPK10PKMRAD52MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183378-B2 | Ligands, their preparation and uses thereof in asymmetric reactions | Li, Chao-Jun (CA) | 2012-05-22 | — | — | US | disclosed |
| US-8183378-B2 | Ligands, their preparation and uses thereof in asymmetric reactions | Li, Chao-Jun (CA) | 2012-05-22 | — | — | US | disclosed |