Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | ESRRB | O95718 | 1/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10623525 | 0.81 | MYC (0.31) | — | |
| SCHEMBL28509099 | 0.81 | KDM4E (0.35) | ESR1ESR2ESRRBESRRAMAPT | |
| SCHEMBL8702455 | 0.79 | CYP1A2 (0.35) | MAPTLMNA | |
| SCHEMBL693400 | 0.76 | NT5E (0.55) | MAPT | |
| SCHEMBL8703720 | 0.76 | AKR1C3 (0.39) | LMNA | |
| SCHEMBL8703308 | 0.75 | ESR1 (0.40) | ESR1ESR2ESRRBESRRA | |
| SCHEMBL8703180 | 0.73 | NCOA1 (0.41) | ESR1ESR2MAPT | |
| SCHEMBL6535469 | 0.73 | MAOA (0.50) | ESR1ESR2ESRRBESRRAMAPT | |
| SCHEMBL8707994 | 0.70 | MAOA (0.31) | MAPTMAOAMAOB | |
| SCHEMBL19689622 | 0.69 | LMNA (0.68) | ESR1ESR2ESRRBESRRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351954-A1 | FARNESYL TRANSFERASE INHIBITING 4-HETEROCYCLYL-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002051834-A1 | FARNESYL TRANSFERASE INHIBITING 4-HETEROCYCLYL-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-07-04 | — | — | WO | disclosed |