Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.40 |
| ▸ | CTSD | P07339 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942460 | 0.87 | ADAM17 (0.46) | CTSKADAM17MMP1MMP2MMP3 | |
| SCHEMBL6979640 | 0.80 | ADAM17 (0.44) | CTSKADAM17MMP1MMP2MMP3 | |
| SCHEMBL6981638 | 0.77 | ADAM17 (0.46) | RENCTSKADAM17MMP2MMP3 | |
| SCHEMBL6982398 | 0.76 | CHRNB2 (0.45) | ADAM17MMP1MMP2MMP3 | |
| SCHEMBL6987317 | 0.76 | ADAM17 (0.44) | RENALDH1A1CTSSCTSKADAM17 | |
| SCHEMBL6942710 | 0.75 | ADAM17 (0.46) | ALDH1A1GAAADAM17MMP1MMP2 | |
| SCHEMBL6224872 | 0.74 | ADAM17 (0.45) | ADAM17 | |
| SCHEMBL6220557 | 0.74 | ADAM17 (0.45) | ADAM17 | |
| SCHEMBL6220793 | 0.74 | ADAM17 (0.45) | ADAM17 | |
| SCHEMBL6223927 | 0.74 | ADAM17 (0.45) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |