Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942460 | 0.89 | ADAM17 (0.46) | ADAM17KMT2AMMP1MMP2MMP3 | |
| SCHEMBL6944742 | 0.88 | CHRNB2 (0.43) | CHRNB2CHRNA4RAB9AADAM17CHRNB4 | |
| SCHEMBL6979640 | 0.81 | ADAM17 (0.44) | ADAM17HDAC3MMP1MMP2MMP3 | |
| SCHEMBL6941589 | 0.80 | ADAM17 (0.49) | CHRNB2CHRNA4RAB9AADAM17TBXAS1 | |
| SCHEMBL6940963 | 0.79 | CTSL (0.41) | CHRNA7 | |
| SCHEMBL6981638 | 0.79 | ADAM17 (0.46) | ADAM17MMP2MMP3MMP7 | |
| SCHEMBL6987317 | 0.78 | ADAM17 (0.44) | ADAM17CYP2C9CYP2C19MMP1MMP2 | |
| SCHEMBL6942710 | 0.77 | ADAM17 (0.46) | ADAM17KMT2ALMNAMMP1MMP2 | |
| SCHEMBL6986685 | 0.76 | REN (0.40) | ADAM17MMP1MMP2MMP3 | |
| SCHEMBL6944086 | 0.76 | ADAM17 (0.42) | ADAM17MEN1KMT2AMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |