Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990765 | 0.84 | PTGS2 (0.44) | KMT2AALDH1A1SMN1; SMN2HTTTSHR | |
| SCHEMBL6986812 | 0.84 | ALDH1A1 (0.40) | KMT2AALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL6985903 | 0.80 | FGFR1 (0.37) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6990503 | 0.79 | TSHR (0.39) | KMT2AALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL6979697 | 0.78 | CYP1A2 (0.44) | KMT2AALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL6987042 | 0.77 | PDE10A (0.37) | KMT2AALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL6982802 | 0.76 | PDE1A (0.36) | KMT2AALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL6983287 | 0.76 | PDE1A (0.36) | KMT2AALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL6987206 | 0.76 | PDE1A (0.36) | KMT2AALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL6985846 | 0.73 | BCL2 (0.41) | KMT2AALDH1A1SMN1; SMN2HTTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |