Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984041 | 0.88 | ROCK2 (0.43) | ROCK2HRH3FAAHACHEHTR4 | |
| SCHEMBL6987182 | 0.88 | FAAH (0.43) | ROCK2HRH3FAAHACHEHTR4 | |
| SCHEMBL6987679 | 0.87 | HTR4 (0.41) | FAAHACHEHTR4KMT2ALMNA | |
| SCHEMBL6982360 | 0.87 | HTR4 (0.42) | ROCK2HRH3FAAHACHEHTR4 | |
| SCHEMBL6985205 | 0.87 | ROCK2 (0.42) | ROCK2HRH3FAAHACHEHTR4 | |
| SCHEMBL6989019 | 0.87 | FAAH (0.42) | ROCK2HRH3FAAHACHEHTR4 | |
| Hydrochloric Acid SCHEMBL6984317 | 0.87 | ROCK2 (0.44) | ROCK2HRH3FAAHACHEHTR4 | |
| Hydrochloric Acid SCHEMBL6984942 | 0.87 | ROCK2 (0.42) | ROCK2HRH3FAAHACHEHTR4 | |
| SCHEMBL6987886 | 0.86 | ROCK2 (0.41) | ROCK2HRH3FAAHACHEHTR4 | |
| SCHEMBL6986867 | 0.85 | ROCK2 (0.41) | ROCK2HRH3FAAHACHEHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289954-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096303-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |