Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 9/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983815 | 0.84 | MMP1 (0.41) | MMP2CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6940361 | 0.81 | ADAM17 (0.37) | BMP1BCHEMMP2PDE4APDE4B | |
| SCHEMBL6220706 | 0.80 | BMP1 (0.33) | BMP1BCHEMMP2PDE4APDE4B | |
| SCHEMBL7838011 | 0.79 | BMP1 (0.34) | BMP1MMP2PDE4APDE4BPDE4C | |
| SCHEMBL6939989 | 0.78 | BCHE (0.39) | BMP1BCHEMMP2CTSDMETAP2 | |
| SCHEMBL6982430 | 0.78 | BCHE (0.30) | BCHE | |
| SCHEMBL6987806 | 0.77 | BCHE (0.37) | BMP1BCHEMMP2METAP2 | |
| SCHEMBL6983937 | 0.76 | ADAM17 (0.42) | MMP2CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6986604 | 0.76 | BMP1 (0.30) | BMP1MMP2 | |
| SCHEMBL6945603 | 0.75 | ADAM17 (0.38) | BMP1MMP2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |