Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 7/20 | 0.35 |
| ▸ | MMP3 | P08254 | 6/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840445 | 0.89 | MMP1 (0.46) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6987301 | 0.84 | BMP1 (0.34) | MMP2CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL4290067 | 0.84 | MMP2 (0.41) | MMP1MMP2MMP3HPGDEPHX2 | |
| SCHEMBL6942326 | 0.84 | MMP1 (0.39) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6940058 | 0.83 | CTSK (0.38) | MMP1MMP13MMP2MMP3CYP1A2 | |
| SCHEMBL6983937 | 0.82 | ADAM17 (0.42) | MMP2APPCCNA2CDK2CCNA1 | |
| SCHEMBL6221034 | 0.82 | MMP1 (0.38) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL7828836 | 0.82 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6986871 | 0.81 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL7835338 | 0.81 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |