Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989070 | 0.88 | LMNA (0.43) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6987318 | 0.80 | CYP3A4 (0.35) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6703223 | 0.77 | ALDH1A1 (0.40) | MAPTPOLBPGRLMNATP53 | |
| SCHEMBL6988241 | 0.76 | PGR (0.41) | PGRKCNA5CNR2TBXA2R | |
| SCHEMBL27670799 | 0.71 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL28134351 | 0.68 | ANO1 (0.41) | LMNAALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL27641592 | 0.67 | HDAC1 (0.38) | LMNAALDH1A1NPC1RAB9ATBXA2R | |
| SCHEMBL6703548 | 0.65 | NPC1 (0.46) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL27797978 | 0.64 | KEAP1 (0.40) | LMNAALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL27667935 | 0.64 | FFAR1 (0.40) | MAPTMEN1ALOX12KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324984-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | Morphochem AG (DE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030892-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | MORPHOCHEM AG (DE) | 2002-04-18 | — | — | WO | disclosed |