Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987344 | 0.88 | MAPT (0.34) | LMNANPC1MAPTKDM4EKMT2A | |
| SCHEMBL7090856 | 0.88 | MAOA (0.38) | LMNANPC1MAPTCASP3SENP8 | |
| SCHEMBL6988241 | 0.82 | PGR (0.41) | — | |
| SCHEMBL6703548 | 0.77 | NPC1 (0.46) | LMNANPC1MAPTCASP3SENP8 | |
| SCHEMBL6704193 | 0.75 | NPC1 (0.47) | LMNANPC1MAPTCASP3SENP8 | |
| SCHEMBL5486246 | 0.73 | NPC1 (0.45) | LMNANPC1MAPTCASP3SENP8 | |
| SCHEMBL27529112 | 0.73 | MAPT (0.45) | LMNANPC1MAPTCASP3SENP8 | |
| SCHEMBL27502700 | 0.70 | ABCB1 (0.53) | LMNANPC1MAPTCASP3SENP8 | |
| SCHEMBL27767996 | 0.69 | MAPK1 (0.40) | LMNANPC1MAPTCASP3SENP8 | |
| SCHEMBL1893211 | 0.68 | ALDH1A1 (0.51) | LMNANPC1MAPTCASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324984-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | Morphochem AG (DE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030892-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | MORPHOCHEM AG (DE) | 2002-04-18 | — | — | WO | disclosed |