Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | C1S | P09871 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516367 | 0.78 | KDM4E (0.45) | LMNABLMRECQLKMT2AKDM4E | |
| SCHEMBL5907451 | 0.78 | F2 (0.34) | F2F10F12F7F3 | |
| SCHEMBL6633093 | 0.77 | PRSS1 (0.36) | F2F10F12F7F3 | |
| SCHEMBL7428707 | 0.72 | GABRA1 (0.38) | F2F10F12F7F3 | |
| SCHEMBL21053816 | 0.72 | WDR5 (0.42) | F2F10F12F7F3 | |
| SCHEMBL18301295 | 0.72 | CA1 (0.43) | LMNAPRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL1191220 | 0.71 | CA2 (0.44) | LMNABLMRECQLKMT2AKDM4E | |
| SCHEMBL8948745 | 0.70 | F2 (0.34) | F2F10F12F7F3 | |
| SCHEMBL1028751 | 0.67 | — | — | |
| SCHEMBL1649597 | 0.67 | F2 (0.38) | F2F10F12F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728758-B1 | Dioxopyrrolo-pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | claimed |
| US-5686459-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-11-11 | — | — | US | claimed |
| EP-0728758-A1 | Dioxopyrrolo-pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1996-08-28 | — | — | EP | claimed |
| US-5532255-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | claimed |
| EP-0728758-B1 | Dioxopyrrolo-pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-5686459-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0728758-A1 | Dioxopyrrolo-pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1996-08-28 | — | — | EP | disclosed |