Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82438 | 0.81 | TDP1 (0.34) | HSD11B1NOTUMALDH1A1TDP1 | |
| SCHEMBL12817256 | 0.81 | HSD11B1 (0.41) | HSD11B1NOTUMCYP3A4ALOX15HSD17B10 | |
| SCHEMBL2431241 | 0.81 | HTR1A (0.33) | HSD11B1NOTUMALDH1A1 | |
| SCHEMBL3416823 | 0.79 | HSD11B1 (0.41) | HSD11B1NOTUMCYP3A4ALOX15HSD17B10 | |
| SCHEMBL6334156 | 0.79 | AR (0.36) | HSD11B1AR | |
| SCHEMBL11032497 | 0.79 | ALDH1A1 (0.38) | HSD11B1HSD17B10MAPK1ALDH1A1 | |
| SCHEMBL3583635 | 0.79 | CYP2A6 (0.38) | HSD11B1ALDH1A1TSHRHPGDAR | |
| SCHEMBL455371 | 0.78 | ALDH1A1 (0.40) | HSD11B1HSD17B10MAPK1ALDH1A1TSHR | |
| SCHEMBL197671 | 0.78 | HSD11B1 (0.56) | HSD11B1NOTUMCYP3A4ALOX15HSD17B10 | |
| SCHEMBL3636361 | 0.78 | HSD11B1 (0.42) | HSD11B1NOTUMCYP3A4ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937051-A1 | FUNGICIDAL CYCLIC AMIDES | E.I. DU PONT DE NEMOURS & COMPANY INCORPORATED (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1998020003-A1 | FUNGICIDAL CYCLIC AMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-05-14 | — | — | WO | claimed |
| EP-1318984-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024667-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |