Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9180114 | 0.80 | CASP3 (0.39) | ALDH1A1CYP2A6KMT2A | |
| SCHEMBL8477327 | 0.79 | ALDH1A1 (0.44) | RAB9ASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL10747888 | 0.76 | STK10 (0.44) | SMN1; SMN2MAPTALDH1A1KDM4EHTT | |
| SCHEMBL9182853 | 0.74 | CASP3 (0.36) | CYP2A6 | |
| SCHEMBL9874776 | 0.71 | RXFP1 (0.52) | RAB9ASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL9874038 | 0.71 | MAPT (0.44) | RAB9ASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL28681845 | 0.70 | MMP3 (0.41) | AR | |
| SCHEMBL31490586 | 0.70 | RXFP1 (0.44) | RAB9ASMN1; SMN2MAPTNPC1RXFP1 | |
| SCHEMBL5869331 | 0.69 | RAB9A (0.60) | RAB9ASMN1; SMN2 | |
| SCHEMBL16781504 | 0.67 | MAPT (0.54) | RAB9ASMN1; SMN2MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276739-A2 | HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME | Bristol-Myers Squibb Company (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001081340-A2 | HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |