Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ESRRA | P11474 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988403 | 0.92 | KMT2A (0.35) | CTSKLMNASMN1; SMN2RAB9AMEN1 | |
| SCHEMBL6989542 | 0.91 | TP53 (0.40) | CTSKESRRGLMNAALDH1A1MAPT | |
| SCHEMBL6990056 | 0.90 | OPRM1 (0.37) | LMNAALDH1A1PDE2A | |
| SCHEMBL6990082 | 0.90 | MAPT (0.41) | ESRRGLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6988433 | 0.89 | TAS1R3 (0.35) | CTSKESRRG | |
| SCHEMBL6988694 | 0.88 | ATM (0.39) | LMNASMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL6981853 | 0.87 | TRPV1 (0.42) | GCGREPHX2 | |
| SCHEMBL6988884 | 0.85 | CTSS (0.36) | CTSKSMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL6985501 | 0.85 | GCGR (0.41) | PDE2AGCGR | |
| SCHEMBL6982132 | 0.85 | TAOK1 (0.36) | LMNARAB9ANPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |