Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 4/20 | 0.37 |
| ▸ | MIF | P14174 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988331 | 0.92 | KDM1A (0.38) | GCGRKDM1APDE2AADAM17DGAT1 | |
| SCHEMBL6989124 | 0.87 | TDP1 (0.42) | — | |
| SCHEMBL6987871 | 0.85 | CTSK (0.39) | GCGRPDE2A | |
| SCHEMBL6753776 | 0.84 | CTSL (0.39) | GCGRKDM1A | |
| SCHEMBL6988403 | 0.84 | KMT2A (0.35) | — | |
| SCHEMBL6989542 | 0.83 | TP53 (0.40) | GCGR | |
| SCHEMBL6990056 | 0.82 | OPRM1 (0.37) | PDE2A | |
| SCHEMBL6990082 | 0.82 | MAPT (0.41) | — | |
| SCHEMBL6751665 | 0.82 | KDM1A (0.42) | KDM1A | |
| SCHEMBL6988433 | 0.82 | TAS1R3 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |