Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.33 |
| ▸ | PLD2 | O14939 | 1/20 | 0.31 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991034 | 0.90 | TAS1R3 (0.34) | TAS1R3TAS1R1PLD2PLD1 | |
| SCHEMBL6987871 | 0.89 | CTSK (0.39) | ESRRGCTSK | |
| SCHEMBL6988403 | 0.88 | KMT2A (0.35) | PLD1CTSK | |
| SCHEMBL6989542 | 0.88 | TP53 (0.40) | ESRRGCTSK | |
| SCHEMBL6990082 | 0.87 | MAPT (0.41) | ESRRG | |
| SCHEMBL6990056 | 0.87 | OPRM1 (0.37) | — | |
| SCHEMBL6988694 | 0.84 | ATM (0.39) | — | |
| SCHEMBL6981853 | 0.84 | TRPV1 (0.42) | — | |
| SCHEMBL6988884 | 0.82 | CTSS (0.36) | CTSK | |
| SCHEMBL6985501 | 0.82 | GCGR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |