Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | CTSE | P14091 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987947 | 1.00 | LMNA (0.37) | LMNACCR5SMN1; SMN2MIFTRPA1 | |
| SCHEMBL11078121 | 0.83 | LMNA (0.35) | LMNACCR5SMN1; SMN2MIFTRPA1 | |
| SCHEMBL11078122 | 0.83 | LMNA (0.35) | LMNACCR5SMN1; SMN2MIFTRPA1 | |
| SCHEMBL3440755 | 0.79 | TAAR1 (0.44) | TRPA1TAAR1TSHRAOC3 | |
| SCHEMBL10640638 | 0.78 | LMNA (0.42) | LMNACCR5MIFTRPA1TAAR1 | |
| SCHEMBL10640640 | 0.78 | LMNA (0.42) | LMNACCR5MIFTRPA1TAAR1 | |
| SCHEMBL5853849 | 0.78 | LMNA (0.42) | LMNACCR5SMN1; SMN2MIFTRPA1 | |
| SCHEMBL5853851 | 0.78 | LMNA (0.42) | LMNACCR5SMN1; SMN2MIFTRPA1 | |
| SCHEMBL996150 | 0.76 | TRPA1 (0.31) | LMNATRPA1TSHR | |
| SCHEMBL996151 | 0.76 | TRPA1 (0.31) | LMNATRPA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6288228-B1 | DIAMINOTRIAZINE DERIVATIVES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |
| US-6150362-A | ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES | ABBVIE INC. | 2000-11-21 | — | — | US | disclosed |
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | disclosed |