Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 8/20 | 0.48 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | ESRRG | P62508 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6751806 | 0.86 | CTSL (0.54) | CTSLCTSBCTSS | |
| SCHEMBL6752373 | 0.82 | HPGDS (0.49) | HPGDSCTSLCTSBCTSSHDAC1 | |
| SCHEMBL6984396 | 0.79 | CTSL (0.43) | HPGDSCTSLCTSBCTSSALDH1A1 | |
| SCHEMBL6985207 | 0.79 | CTSK (0.46) | TACR2 | |
| SCHEMBL6753779 | 0.79 | CTSL (0.37) | HPGDSCTSLCTSBCTSS | |
| SCHEMBL6988397 | 0.79 | CTSL (0.43) | CTSLCTSBCTSS | |
| SCHEMBL6747828 | 0.78 | CTSL (0.47) | HPGDSCTSLCTSBCTSS | |
| SCHEMBL6747644 | 0.78 | CTSL (0.42) | ESRRGCTSLCTSBCTSS | |
| SCHEMBL6747731 | 0.78 | CTSL (0.42) | TACR2ESRRGCTSLCTSBCTSS | |
| SCHEMBL6749679 | 0.77 | CTSL (0.42) | CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |