Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 5/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985512 | 0.88 | KDM4E (0.45) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL7098081 | 0.79 | ACHE (0.41) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL7140810 | 0.79 | ACHE (0.41) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL6986644 | 0.77 | F10 (0.43) | ALDH1A1CHRM2F10 | |
| SCHEMBL5868270 | 0.73 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL6984942 | 0.73 | ROCK2 (0.42) | ALDH1A1MAPTF10HTR4 | |
| SCHEMBL6989025 | 0.73 | HTR4 (0.43) | ALDH1A1HTR4 | |
| SCHEMBL5868023 | 0.71 | KDM4E (0.48) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL6987891 | 0.71 | F10 (0.38) | ALDH1A1KDM4EF10CCR3 | |
| SCHEMBL5868145 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289954-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096303-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |