Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | HTR1B | P28222 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087898 | 0.86 | HTR2C (0.49) | HTR2BHTR2CHTR1AHTR2ACYP2D6 | |
| SCHEMBL6510961 | 0.85 | THRB (0.54) | HTR2BHTR2CHTR1AHTR2ATHRA | |
| SCHEMBL6515823 | 0.84 | KDM4E (0.48) | HTR2BHTR2CHTR1AHTR2AHTR1B | |
| SCHEMBL6984598 | 0.80 | HTR2C (0.53) | HTR2BHTR2CHTR1AHTR2ACYP2D6 | |
| SCHEMBL6512855 | 0.79 | THRB (0.51) | HTR2BHTR2CHTR1AHTR2ATHRA | |
| SCHEMBL6981325 | 0.79 | THRA (0.48) | HTR2BHTR2CHTR1AHTR2ACYP2D6 | |
| SCHEMBL6520704 | 0.78 | THRA (0.48) | HTR2BHTR2CHTR1AHTR2ATHRA | |
| SCHEMBL6511324 | 0.78 | THRA (0.52) | THRATHRBKDM4E | |
| SCHEMBL6985214 | 0.78 | CYP2D6 (0.45) | HTR2CHTR1AHTR2ACYP2D6CYP1A2 | |
| SCHEMBL6511399 | 0.78 | KDM4E (0.44) | HTR2BHTR2CHTR1AHTR2ATHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |