Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 3/20 | 0.44 |
| ▸ | DAO | P14920 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | RHEB | Q15382 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | DDO | Q99489 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989136 | 0.90 | DAO (0.49) | SIGMAR1DRD3DRD4DRD5DRD1 | |
| SCHEMBL6989299 | 0.88 | LOXL2 (0.57) | DAOLOXL2PCSK9CNR1 | |
| SCHEMBL6990951 | 0.87 | DAO (0.49) | DAOPCSK9CNR1DDO | |
| SCHEMBL6994150 | 0.81 | DAO (0.44) | DAOLOXL2PCSK9DDO | |
| SCHEMBL6943878 | 0.81 | DAO (0.40) | DAOGPR183CNR1DDO | |
| SCHEMBL6993860 | 0.81 | DAO (0.44) | SIGMAR1DRD3DRD4DRD5DRD1 | |
| SCHEMBL6994522 | 0.79 | LOXL2 (0.53) | DRD3DRD4LOXL2PCSK9CNR1 | |
| SCHEMBL6993972 | 0.78 | DAO (0.44) | DAOLOXL2PCSK9CNR1DDO | |
| SCHEMBL7500914 | 0.78 | DRD4 (0.44) | SIGMAR1DRD3DRD4DRD5DRD1 | |
| SCHEMBL6826452 | 0.77 | LOXL2 (0.64) | DAOLOXL2PCSK9RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |