Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.34 |
| ▸ | SELE | P16581 | 2/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990452 | 0.82 | ALDH1A1 (0.49) | ALDH1A1ICAM1SELEVCAM1POLB | |
| SCHEMBL1720297 | 0.80 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL6992257 | 0.78 | MAPT (0.42) | ALDH1A1ICAM1SELEVCAM1MAPT | |
| SCHEMBL6994384 | 0.78 | ALDH1A1 (0.50) | ALDH1A1ICAM1SELEVCAM1MAPT | |
| SCHEMBL6987163 | 0.75 | MAPT (0.38) | ICAM1SELEVCAM1MAPT | |
| SCHEMBL6991176 | 0.75 | ICAM1 (0.43) | ALDH1A1ICAM1SELEVCAM1POLB | |
| SCHEMBL8043809 | 0.74 | FBP1 (0.42) | ALDH1A1POLB | |
| SCHEMBL6988762 | 0.72 | MAPT (0.38) | ICAM1SELEVCAM1MAPT | |
| SCHEMBL6989319 | 0.71 | ALDH1A1 (0.35) | ALDH1A1ICAM1SELEVCAM1MAPT | |
| SCHEMBL8044324 | 0.70 | ALDH1A1 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452683-A2 | Methods for treating atherosclerosis | Amgen Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2037928-B1 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2008002591-A2 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2008-01-03 | — | — | WO | disclosed |