Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994384 | 0.84 | ALDH1A1 (0.50) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6992257 | 0.81 | MAPT (0.42) | ALDH1A1NPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL1719384 | 0.80 | KMT2A (0.35) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL6990452 | 0.79 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6987163 | 0.79 | MAPT (0.38) | MAPTICAM1SELEVCAM1 | |
| SCHEMBL6990637 | 0.77 | TSHR (0.37) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL19726462 | 0.76 | ALDH1A1 (0.52) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL6991176 | 0.75 | ICAM1 (0.43) | ALDH1A1NPC1RAB9AGAAMAPT | |
| SCHEMBL6987084 | 0.75 | LMNA (0.50) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL6988762 | 0.72 | MAPT (0.38) | MAPTICAM1SELEVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452683-A2 | Methods for treating atherosclerosis | Amgen Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2037928-B1 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2008002591-A2 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2008-01-03 | — | — | WO | disclosed |