Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990452 | 0.92 | ALDH1A1 (0.49) | MAPTSMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL6994384 | 0.88 | ALDH1A1 (0.50) | MAPTSMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL6989319 | 0.81 | ALDH1A1 (0.35) | MAPTSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL6987163 | 0.80 | MAPT (0.38) | MAPTPTGS1PTGS2ICAM1SELE | |
| SCHEMBL1720086 | 0.79 | SMN1; SMN2 (0.40) | MAPTSMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL6989328 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1ICAM1SELEVCAM1 | |
| SCHEMBL6991176 | 0.76 | ICAM1 (0.43) | MAPTALDH1A1LMNATP53HSD17B10 | |
| SCHEMBL6987084 | 0.76 | LMNA (0.50) | MAPTSMN1; SMN2ALDH1A1KMT2ALMNA | |
| SCHEMBL6988762 | 0.73 | MAPT (0.38) | MAPTICAM1SELEVCAM1 | |
| SCHEMBL1719387 | 0.71 | ALDH1A1 (0.40) | MAPTSMN1; SMN2ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452683-A2 | Methods for treating atherosclerosis | Amgen Inc. (US) | 2012-05-16 | — | — | EP | disclosed |