Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992257 | 0.88 | MAPT (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL6990452 | 0.85 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL6989319 | 0.84 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AICAM1 | |
| SCHEMBL6987163 | 0.82 | MAPT (0.38) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL6991176 | 0.79 | ICAM1 (0.43) | ALDH1A1NPC1RAB9ALMNATP53 | |
| SCHEMBL6987084 | 0.79 | LMNA (0.50) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1719815 | 0.78 | ALDH1A1 (0.39) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6989328 | 0.78 | ALDH1A1 (0.43) | ALDH1A1ICAM1SELEVCAM1MAPT | |
| SCHEMBL6988762 | 0.76 | MAPT (0.38) | ICAM1SELEVCAM1MAPT | |
| SCHEMBL1104190 | 0.73 | ALDH1A1 (0.70) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452683-A2 | Methods for treating atherosclerosis | Amgen Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2037928-B1 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2008002591-A2 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2008-01-03 | — | — | WO | disclosed |