Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.84 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930390 | 0.92 | KEAP1 (1.00) | KEAP1NFE2L2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2076642 | 0.92 | KEAP1 (0.68) | KEAP1NFE2L2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL8675450 | 0.84 | ALDH1A1 (0.70) | KEAP1NFE2L2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL7121384 | 0.84 | KEAP1 (0.86) | KEAP1NFE2L2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL27637350 | 0.83 | KEAP1 (0.83) | KEAP1NFE2L2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2402121 | 0.79 | ALDH1A1 (0.50) | KEAP1NFE2L2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL3605803 | 0.79 | KEAP1 (0.75) | KEAP1NFE2L2ALDH1A1GRK6MAPT | |
| SCHEMBL678363 | 0.78 | ALDH1A1 (0.70) | KEAP1NFE2L2ALDH1A1L3MBTL1POLB | |
| SCHEMBL7829487 | 0.78 | KEAP1 (0.73) | KEAP1NFE2L2ALDH1A1L3MBTL1POLB | |
| SCHEMBL11835545 | 0.76 | TTR (0.49) | KEAP1NFE2L2ALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |